| Properties |
| Minute crystals from ethyl acetate, mp 87-89° Hygroscopic. [alpha]D20 -147°(H2O, alcohol, or acetone). Shows mutarotation [alpha]D20 -127°after 9°hrs (H2O). Freely sol in acetone, ethanol, methanol, pyridine, glacial acetic acid, 5% a |
| Synthesis: Bitter principle of olives, Olea europaea, isol. also from Fraxina japonicus. |
| Physics Description: Cryst. (EtOAc). |
| Melting Point: Mp 89-91 deg |
| Partition Coefficient: Log P -1.75 (uncertain value) (calc). |
| Other Data: Artifact. |
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| Use |
| Antihypertensive agent. |
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| Reference |
| Shasha, B. et al.,J.O.C.,1961, 26, 1948 (isol) Panizzi, L. et al.,Gazz. Chim. Ital.,1965, 95, 1279 (isol) Asaka, Y. et al.,Chem. Lett.,1972, 141 (isol, struct) Inouye, H. et al.,Chem. Pharm. Bull.,1974, 22, 676 (biosynth) Inouye, H. et al.,Tetrahedron,1974, 30, 201 (abs config) Inouye, H. et al.,Phytochemistry,1975, 14, 304; ,2029; ,1982, 21, 2305 (isol, 10-Acetoxyoleuropein, 10-Acetoxyligustroside) Inouye, H. et al.,J. Chromatogr.,1976, 118, 201 (ms) Sutarjadi, M.T.M. et al.,Phytochemistry,1978, 17, 564 (Ligustroside) Kikuchi, M. et al.,CA,1985, 103, 147026 (isol, pmr, cmr) Shen, Y.-C. et al.,Phytochemistry,1990, 29, 2903; ,2905 (Multiroside, Ligustroside) Bianco, A. et al.,J. Nat. Prod.,1992, 55, 760 (synth) Damtoft, S. et al.,Phytochemistry,1992, 31, 4197; ,1993, 34, 1291; ,1995, 40, 785 (biosynth, Oleuropein, Ligustroside) Calis, I. et al.,Phytochemistry,1993, 33, 1453 (Angustifoliosides) Shen, Y.C. et al.,Planta Med.,1995, 61, 281 (Uhdenoside) Shen, Y.-C., J. Chin. Chem. Soc. (Peking),1996, 43, 171 (pmr, cmr) Tanahashi, T. et al.,Chem. Pharm. Bull.,1997, 45, 367 (4"-Glucopyranosyloleuropein) [00023532-9] |
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![Oleuropein, Methyl (4S,5E,6S)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate, Olive Leaf Extract CAS #: 32619-42-4](http://www.chemicalall.com/wp-content/uploads/2008/07/015057h7a.gif)
