| Properties |
| Bitter crystals, mp 255-260° uv max (ethanol): 223, 270, 280, 287, 291 nm (E1%1cm 3622, 239, 286, 196, 198). pKa (25°C) 10.35 +/-0.02, (35°C) 10.13 +/-0.02, (45°C) 9.92 +/-0.03. pKa (25°C) 10.35 +/-0.02, (35°C) 10.13 +/-0.02, (45°C |
| Hazard Toxicity: LD50 (rat, scu) 385 mg/kg. LD50 (mus, orl) 270 mg/kg. |
| Partition Coefficient: Log P 3.83 (calc). |
|
| Use |
| .alpha.-Adrenoceptor agonist. Vasoconstrictor, sym |
|
| Synonym |
| 2-(1-naphthylmethyl)imidazoline |
| 萘唑啉 |
| 2-(1-萘甲基)-2-咪唑啉 |
| 鼻眼净 |
| 滴鼻净 |
| 拿发坐林 |
| Albacon |
| Albalon |
| Albasol |
| Anamur |
| Antan |
| Araff |
| Arcovil0-Debil |
| Benil |
| Biogan |
| Cefasan |
| Clasol |
| Clear Eyes |
| Clera |
| Coldan |
| Colirio Alfa |
| Dazolin |
| Descongestionante nasal "Fortuny" |
| Enflucide |
| Fazolan |
| Fluitting |
| Gotinal |
| "Imidazolina" |
| Imidazyl |
| Imidin |
| Imizol "Farmigea" |
| Iprasan |
| Klinofazol |
| Medicoryn |
| Myralon |
| Nafazol |
| Nafazair |
| Nafazolin |
| Nafazolina |
| Nafin |
| Naftazolina |
| Naphacel |
| Naphazoline |
| Naphcon |
| Naphol |
| Naphtazoline |
| Naphthizin |
| Naphthizinum |
| Naphthyzin |
| Nasal Yer |
| Nastizol |
| Nazil |
| Niazol |
| Ninazo |
| Noselit |
| Ocunasal |
| Opticon |
| Pentakos |
| Pentazoline |
| Pertiran |
| Pervil |
| Pivanol |
| Privamida |
| Privin |
| Prizole |
| Prizolene |
| Proculin |
| Ran |
| Refanizol |
| Rhinal |
| Rhinantin |
| Rhinazin |
| Rhinex |
| Rhinonl |
| Rhinoperd |
| Rimidol |
| Rinazina |
| Rinitol |
| Rinofug |
| Rino-Naftazolina |
| Rinozin |
| Sanorin |
| S-Mogfen |
| Soltrictor |
| Stanazoline |
| Strictylon |
| Vasoclear |
| Vasocon |
| Vasocon-Regular |
| Vasoconstrictor-Pensa |
| Vistalbalon |
| Naphazoline,BAN,INN |
| 4,5-Dihydro-2-(1-naphthalenylmethyl)-1H-imidazole,9CI |
| 2-(1-Naphthylmethyl)-2-imidazoline,8CI |
| Momentol |
|
| Reference |
| Aldrich Library of 13C and 1H FT NMR Spectra,1992, 2, 643A (nmr) Aldrich Library of FT-IR Spectra, 1st edn.,1985, 1, 1305C (ir) Danish Pat.,1945, 62 889; CA,40, 4398 (synth) Villa, L. et al.,Farmaco, Ed. Sci.,1967, 22, 491 (pharmacol) Kracmar, J. et al.,Cesk. Farm.,1972, 21, 48 (uv) Pullman, B. et al.,J. Med. Chem.,1972, 15, 17 (struct) Piskov, V.B. et al.,Khim. Prir. Soedin.,1976, 8, 1112 (synth) De Jong, A.P. et al.,J. Med. Chem.,1979, 22, 1290 (struct) Podder, A. et al.,Acta Cryst. C,1983, 39, 495 (cryst struct) Negwer, M., Organic-Chemical Drugs and their Synonyms,6th edn., Akademie-Verlag, Berlin, 1987, 3087 Wall, G.M., Anal. Profiles Drug Subst.,1992, 21, 307 (rev) Martindale, The Extra Pharmacopoeia,30th edn., Pharmaceutical Press, London, 1993, 1249 Lewis, R.J., Sax’s Dangerous Properties of Industrial Materials,8th edn., Van Nostrand Reinhold, 1992, NAH500; ,NAH550; , NCW000 [00070796-2] |
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