| Identification |
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Name
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Levothyroxine sodium
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|
Synonyms
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Sodium 4-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
|
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Chinese Names
|
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左旋甲状腺素钠; 左甲状腺素钠
|
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Molecular Structure
|
|
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|
|
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Molecular Formula
|
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C15H10I4NNaO4
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Molecular Weight
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798.86
|
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CAS Registry Number
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55-03-8
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EINECS
|
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200-221-4
|
| Properties |
| Purity(Titration): min. 98% |
| Specific rotation [a]20/D: +15+ to +17 deg.(c=1,1mol/l HCl-Ethanol95 /1-4) |
| Hazard Toxicity: Adverse human effects when used therapeutically (corresponding with symptoms of hyperthyroidism). LD50 (rat, ipr) 20 mg/kg. Exp. reprod. and teratogenic effects. |
| Development Status: Worldwide 97th best selling prescription drug ($0.31 bn) (BASF) (1996, PharmaBusiness). |
| Physics Description: Triclinic cryst. or cream-coloured powder (as pentahydrate). |
| Melting Point: Mp 207-210 deg dec. (pentahydrate) |
| Other Data: Component of Liotrix, USAN, Euthroid and Thyrolar. |
|
| Synonym |
| L-Thyroxine Sodium Salt |
| Thyroxine,BAN;(S)-form;Na salt |
| Levothyroxine sodium,INN,USAN |
| Levothroid |
| Synthroid |
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